N,N-dibutylcarbamoyl chloride
Dibutylcarbamyl Chloride
CAS: 13358-73-1
Molecular Formula: C9H18ClNO
N,N-dibutylcarbamoyl chloride - Names and Identifiers
| Name | Dibutylcarbamyl Chloride |
| Synonyms | tl459 Brn 2040828 Dibutylcarbamyl Chloride dibutylcarbamoylchloride dibutyl-carbamoylchlorid dibutylcarbamic chloride DIBUTYLCARBAMYL CHLORIDE 1,6-dibutyl-carbamicchlorid N,N-dibutylcarbamoyl chloride Dibutylcarbamic acid chloride |
| CAS | 13358-73-1 |
| EINECS | 236-410-3 |
| InChI | InChI=1/C9H18ClNO/c1-3-5-7-11(9(10)12)8-6-4-2/h3-8H2,1-2H3 |
N,N-dibutylcarbamoyl chloride - Physico-chemical Properties
| Molecular Formula | C9H18ClNO |
| Molar Mass | 191.7 |
| Density | 0.985g/mLat 25°C(lit.) |
| Boling Point | 257-260°C(lit.) |
| Flash Point | 110°C |
| Vapor Presure | 0.0103mmHg at 25°C |
| pKa | -1.85±0.70(Predicted) |
| Refractive Index | n20/D 1.456(lit.) |
| Physical and Chemical Properties | WGK Germany:3 RTECS:FD2230000 |
N,N-dibutylcarbamoyl chloride - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | 34 - Causes burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3265 8/PG 3 |
| WGK Germany | 3 |
| RTECS | FD2230000 |
| Hazard Class | IRRITANT |
N,N-dibutylcarbamoyl chloride - Introduction
Dibutyl carbamoyl chloride, chemical formula (CH3)2 CHCH2CONHCl, also can be abbreviated as Boc-Cl, is an organic compound.
Nature:
Dibutyl carbamoyl chloride is a colorless liquid with a pungent odor. It is soluble in some organic solvents, such as diethyl ether and dichloromethane. It can be decomposed in the air, so it needs attention during storage and operation.
Use:
Dibutyl carbamoyl chloride is often used as a protecting group in organic synthesis to protect the reactivity of amino or alcohol groups. It can react with amines or alcohols to generate the corresponding Boc protecting group compounds, which have important applications in organic synthesis.
Preparation Method:
Dibutyl carbamoyl chloride is typically prepared by reacting butyl carbamoyl chloride with dimethylformamide. The specific preparation method is that butyl carbamoyl chloride is slowly added dropwise in dimethylformamide to react to obtain dibutyl carbamoyl chloride.
Safety Information:
Dibutyl carbamoyl chloride is irritating and corrosive, and can cause irritation and corrosion in contact with skin and eyes. Wear appropriate personal protective equipment and avoid direct contact with skin and eyes. During use and storage, attention should be paid to avoid contact with oxygen to prevent unnecessary decomposition. In addition, attention should be paid to fire and explosion prevention measures, and proper storage and disposal of waste.
Nature:
Dibutyl carbamoyl chloride is a colorless liquid with a pungent odor. It is soluble in some organic solvents, such as diethyl ether and dichloromethane. It can be decomposed in the air, so it needs attention during storage and operation.
Use:
Dibutyl carbamoyl chloride is often used as a protecting group in organic synthesis to protect the reactivity of amino or alcohol groups. It can react with amines or alcohols to generate the corresponding Boc protecting group compounds, which have important applications in organic synthesis.
Preparation Method:
Dibutyl carbamoyl chloride is typically prepared by reacting butyl carbamoyl chloride with dimethylformamide. The specific preparation method is that butyl carbamoyl chloride is slowly added dropwise in dimethylformamide to react to obtain dibutyl carbamoyl chloride.
Safety Information:
Dibutyl carbamoyl chloride is irritating and corrosive, and can cause irritation and corrosion in contact with skin and eyes. Wear appropriate personal protective equipment and avoid direct contact with skin and eyes. During use and storage, attention should be paid to avoid contact with oxygen to prevent unnecessary decomposition. In addition, attention should be paid to fire and explosion prevention measures, and proper storage and disposal of waste.
Last Update：2024-04-10 22:29:15
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